Joseph Sloop

As an educator, Dr. Joseph Sloop is committed to classroom and laboratory instruction and strongly believes that effective teaching requires an underlying philosophy of both how and what one learns. These components of learning are constructed in the mind of the student, he believes; knowledge cannot be transferred directly from the teacher to the learner, so the teacher must call on the totality of his or her own experience to inspire and facilitate learning in each student.

Sloop's teaching experience includes Physical Science, Survey of Chemistry II, General Chemistry, Introductory Organic Chemistry I/II, Organic Chemistry for Environmental Engineers, Advanced Organic Chemistry, Environmental Toxicology and Chemical and Biological Warfare Agents. His research interests include the synthesis of fluorinated heterocycles and biologically important triketones via fluorine-containing synthons and direct fluorination techniques. He is also interested in LFER and QSAR studies of organic reaction systems, as well as kinetics and thermodynamic studies of aldol condensations.

Sloop’s chemistry text, Succeeding in Organic Chemistry: A Systematic Problem-Solving Approach to Mastering Structure, Function and Mechanism (AuthorHouse Publishing) was published in 2010 and has been well-received. Along with GGC undergraduate students and faculty colleagues, he is also a co-author of several recent scientific articles, including “Cyclodehydration and Baker-Venkataraman rearrangement methodologies for the preparation of fluorinated 4H-chromones” (2020), “Molecular dynamics simulations of the interactions between triose phosphate isomerase and sulfonamides” (2020) as well as the edited book chapter titled “Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products,” in Current Perspectives on Chemical Sciences, Volume 2 (Book Publisher International) published in 2020.

• Doctorate – chemistry – North Carolina State University
• Master's – organic chemistry – North Carolina State University
• Bachelor's – chemistry – Davidson College

• Learning strategies for undergraduate research students
• Improving study techniques for students in organic chemistry

Articles

• Forlemu N. Y., Sloop J. “Molecular dynamics simulations of the interactions between triose phosphate isomerase and sulfonamides,” PeerJ Physical Chemistry, 2020, 2:e13, 1-23.
• Encarnacion-Thomas, E., Sommer, R., Mallia, A., Sloop, J. “(E)-2-(3, 5-Dimethoxybenzylidene) indan-1-one,” IUCRData, 2020, 5, x200759.
• Fernandes, C., Park, S. H., Sloop, J., Wilmott, K. “Cyclodehydration and Baker-Venkataraman rearrangement methodologies for the preparation of fluorinated 4H-chromones,” Chemical Methodologies, 2020, 4, 554-564.
• Haining, R., Sloop, J.C. “A New Model for Advanced Undergraduate Chemistry Laboratory Courses: A Two-semester Integrated Laboratory Experience,” Journal of Laboratory Chemistry Education, 2018, 6(2), 24-30.
• Forlemu, N., Mukinay C., Babalola, R., Sloop, J. “Targeting the Plasmodium Falciparum Folate Pathway: Molecular Modeling of the Affinity of Sulfonamide Derivatives and Isoforms of Dihydrofolate Reductase Thymidylate Synthase,” Journal of Undergraduate Chemistry Research, 2017, 16(2), 68-71.
• Coppock, P., Park, S., Pennington, R., Pursell, D., Rudd, G., Sloop, J.C., Tsoi, M.Y. “Enhancing Research Skills and Attitudes in Undergraduate Organic Chemistry with a Course-embedded Undergraduate Research Experience (CURE) via Green Organic Synthesis,” Journal of Laboratory Chemistry Education, 2017, 5(3), 41-47.
• Sloop, J. “Advances in the Preparation of Fluorinated Isoquinolines: A Decade of Progress,” Journal of Chemistry, 2017, 2017(4), 15 pages.
• Forlemu, N., Watkins, P., Sloop, J. “Molecular Docking of Selective Binding Affinity of Sulfonamide Derivatives as Potential Antimalarial Agents Targeting the Glycolytic Enzymes: GAPDH, Aldolase and TPI,” Open Journal of Biophysics, 2017, 7 (1), 41-57.
• Sloop, J., Tsoi, M., Coppock, P. “Benefits of Using a Problem-Solving Scaffold for Teaching and Learning Synthesis in Undergraduate Organic Chemistry I,” International Journal for the Scholarship of Teaching and Learning, 2016, (10)1, Article 8.
• Barakat, A., Al-Majid, A., Soliman, S., Lotfy, G., Ghabbour, H., Fun, H., Wadood, A., Warad, I., Sloop, J. “New Diethyl Ammonium Salt of Thiobarbituric Acid Derivative: Synthesis, Molecular Structure Investigations and Docking Studies,” Molecules, 2015, 20(11), 20642-20658.
• Sloop, J., Holder, C. Henary, M. “Selective Incorporation of Fluorine in Pyrazoles,” 2015, Eur. J. Org.Chem., 2015, 16, 3405-3422.
• Sloop, J., Churley, M.*, Guzman, A.*, Moseley, S.*, Stalker, S.*, Weyand, J., Yi, J.*. “Synthesis and Reactivity of Fluorinated Cyclic Ketones: Initial Findings,” American Journal of Organic Chemistry, 2014, 1(1), 1-10.
• Sloop, J., Anagho, L., Coppock, P., Giles, G., Park, S., Pennington, R., Pursell, D., Rudd, G., Tsoi, M. Y. “Conformational Analysis, Modeling, Stereochemistry and Optical Activity of Cyclohexane Derivatives,” Journal of Laboratory Chemistry Education, 2013, 1(3), 39-44.
• Sloop, J., Boyle, P., Fountain, A.W., Gomez, C.*, Jackson, J., Pearman, W., Schmidt, R., Weyand, J.* “Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features,” Appl. Sci. Special Edition: Organo-Fluorine Chemical Science, 2012, 2, 61-99.
• Sloop, J., Shultz, D., Coote, T., Shepler, B., Sullivan, U., Kampf, J., Boyle, P. “Synthesis of and Structure-Property Relationships in Zinc Complexes of Bis-Metaphenylene Semiquinone Biradical Species,” J. Phys. Org. Chem., 2012, 25(4), 314-321.
• Sloop, J., Shultz, D., Beikmohammadi, M., Shepler, B. “Linear Free Energy Relationships in Semiquinone Species and Their Mn(II) and Cu(II) Complexes,” J. Phys. Org. Chem., 2012, 25(2), 101-109.
• Sloop, J., Boyle, P., Fountain, A., Pearman, W., Swann, J.*. “Electron deficient aryl b-diketones: synthesis and novel tautomeric preferences,” Eur. J. Org. Chem., 2011, 5, 936-941.
• Paredes, J., Pennington, R., Pursell, D., Sloop, J., Tsoi, M. “Engaging Science Students with Handheld Technology and Applications by Revisiting the Thayer Method of Teaching and Learning,” Journal of Systemics, Cybernetics and Informatics, 2011, 9(7), 46-50.
• Pennington, R., Pursell, D., Sloop, J. “Engaging Science Students with Wireless Technology and Applications by Revisiting the Thayer Method of Teaching and Learning,” Proceedings of the International Multi-Conference on Complexity, Informatics and Cybernetics, 2010, 303-308.
• Sloop, J., Jackson, J., Schmidt, R. “Microwave-Mediated Pyrazole Fluorinations Using Selectfluor®,” Heteroatom Chem., 2009, 20(6), 341-345.
• Sloop, J. “Quinoline Formation: Examination of Kinetics and Mechanistic Pathways,” J. Phys. Org. Chem., 2009, 22 (2), 110-117.
• Armstrong, M., Comitz, R., Biaglow, A., LaChance, R., Sloop, J. “Interdisciplinary Learning for Chemical Engineering Students from Organic Chemistry: Synthesis Lab to Reactor Design to Separation,” J. Chem. Eng. Ed., 2008, 42 (4), 193-200.
• Sloop, J., Lechner, B.*, Washington, G., Bumgardner, C., Loehle, W., Creasy, W. “Pyrazole Formation: Examination of Kinetics and Mechanistic Pathways,” Int. J. Chem. Kinetics, 2008, 40, 370-383.
• Shultz, D., Sloop, J., Coote, T., Beikmohammadi-Marcus, M.*, Kampf, J., Boyle, P. “Substituent Effects on Exchange Coupling: 5-Aryl-Substituted Semiquinones and Their Complexes with MnII and CuII,” Inorg. Chem. 2007, 46, 273-277.
• Shultz, D., Sloop, J., Washington, G. “Design, Synthesis and Properties of Conformationally Fixed Semiquinone Monoradical Species,” J. Org. Chem. 2006, 71, 9104-9113.
• Sloop, J., Bumgardner, C., Washington, G., Loehle, W., Sankar, S., Lewis, A.*. “Keto-Enol and Enol-Enol Tautomerism in Trifluoromethyl-1,3-Diketones,” J. Fluorine Chem. 2006, 127, 780-786.
• Sloop, J., Bumgardner, C., Loehle, W.D. "Synthesis of Fluorinated Heterocycles,” J. Fluorine Chem. 2002, 118, 135-147.
• Sloop, J. "Microscale Synthesis of the Natural Products Carpanone and Piperine," J. Chem. Ed. 1995, 72 (2), A25-27.
• Bumgardner, C., Sloop, J. "Ring Fluorinated Pyrazoles," J. Fluorine Chem. 1992, 56, p. 141-146.
• Carroll, F., Sloop, J.*, Green, D.* "The Norbornadiene Dicarboxylic Acid - Quadricyclane Dicarboxylic Acid Energy Storage System," Solar Energy, 1985, 33 (3/4), p. 377-379.

Books/Book Chapters Authored

• Boyle, P., Breaud, D., Churley, M., Coppock, Jr., P., Encarnacion-Thomas, E., Fernandes, C., Fountain, A., Gomez, C., Guzman, A., Jackson, J., Lam, L., Mallia, A., Moseley, S., Park, S., Pearman, W., Schmidt, R., Sloop, J., Sommer, R., Stalker, S., Weyand, J., Wilmott, K., Yi, J. “Synthesis and Structural Features of Indanone, Tetralone and Naphthone Derivatives: Selective Fluorination and Condensation Products,” in Current Perspectives on Chemical Sciences, Volume 2, edited by Harekrushna Sutar, Book Publisher International, London, UK, 2020.
• Pursell, D., Sloop, J., Pennington, R., Paredes, J., Tsoi, M., Dekhane, S. “Enabling 21st Century Student Success in Undergraduate Organic Chemistry,” in Advances in Teaching Organic Chemistry, ACS Books, Washington, DC, 2012.
• Sloop, J., Pennington, R., Tsoi, M., Paredes, J., Pursell, D., Coppock, P., Giles, G. Laboratory Text for Chem 2211K/2212K Organic Chemistry, edited and compiled by Joseph C. Sloop, Georgia Gwinnett College, GA, 2012.
• Sloop, J., Boyle, P., Fountain, A., Gomez, C., Jackson, J., Pearman, W., Schmidt, R., Weyand, J. “Novel Fluorinated Indanone, Tetralone and Naphthone Derivatives: Synthesis and Unique Structural Features,” in Organo-Fluorine Science – Inventing the Fluorine Future, edited by Helmut M. Hügel, Applied Sciences, MDPI, Basel, SW, 2012.
• Sloop, J. Succeeding in Organic Chemistry: A Systematic Problem-Solving Approach to Mastering Structure, Function and Mechanism, AuthorHouse Publishing Co., Bloomington, IN, 2010.
• Gilbert, J., Martin, S., Tsoi, M., Pennington, R., Pursell, D., Sloop, J. Laboratory Manual for Chem 2211K/2212K Organic Chemistry, edited and compiled by M. Y. Tsoi, Cengage Learning, OH, 2010.
• Sloop, J. “Selective Incorporation of Fluorine in Heterocyclic Molecules,” in Fluorine Chemistry Research Advances, edited by Ira V. Gardiner, Nova Science Publishers, Inc., NY, 2007.
• Sloop, J. Substituent Effects on Spin Density Distribution and Exchange Coupling in Semiquinone Complexes, North Carolina State University, NC, 2003.
• Sloop, J. Synthesis of Ring Fluorinated Pyrazoles and Isoxazoles: The Effect of 2-Fluoro and 2-Chloro Substituents on the Keto-enol Equilibria of 1,3-Diketones, North Carolina State University, NC, 1990.

• Governor's Teaching Fellows Program, 2016
• GGC CTE Teaching Fellows Program, 2016
• GGC Master Teacher Program, 2013
• GGC Scholarly and Creative Activities Award, 2012
• Co-recipient, Blackboard Catalyst Award, 2012
• Biltmore Who’s Who in North American Education, 2012
• Co-recipient, TAG Excalibur Award, 2011
• Marquis Who’s Who in Science and Engineering, 2008
• Phi Kappa Phi Scholastic Achievement Award, 2008
• Gamma Sigma Epsilon National Chemistry Honor Society Inductee, 2006
• USMA Junior Faculty Teaching Award, 1993
• Phi Kappa Phi National Honor Society Inductee, 1989
• Phi Lambda Upsilon Chemistry Honor Society Inductee, 1989